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The billion-dollar COVID booster discussion

Pfizer said yesterday that it expects to sell nearly $34 billion worth of coronavirus vaccines this year — and there could be billions more behind that, if people who have gotten the shot ultimately need boosters.

Why it matters: It's unclear whether, when and for whom a coronavirus vaccine booster will be necessary. Pfizer has a lot of money riding on those answers, and executives are already making the case that many Americans will need a third dose.


What they're saying: Pfizer released new data, not yet peer-reviewed, that suggests the vaccine's efficacy diminishes over time — from 96% in the first two months after receiving the second dose, to 84% after four months.

  • Reduced efficacy could mean more transmission of the virus.
  • "We are very, very confident a third dose, a booster, will take up the immune response to levels that will be enough to protect against the Delta variant," Pfizer CEO Albert Bourla told CNBC yesterday.

Yes, but: The same data show the vaccine was still 97% effective in preventing severe disease, across a full six months of monitoring.

  • Those findings reinforce the FDA and CDC stances that people may not need booster shots at this time.

By the numbers: Pfizer increased its sales estimates yesterday for the doses it has already committed to sell. The company expects those sales to total $33.5 billion this year, almost a 30% jump from its previous estimates — without accounting for sales of any potential boosters.

What's next: "The [vaccine sales] numbers are going to be much higher," Bernstein analyst Ronny Gal wrote to investors, estimating Pfizer's sales could be as high as $43 billion this year.

  • "We expect total sales growth will slow over the next 12 months as COVID-19 vaccine demand shifts toward emerging markets where pricing is lower," analysts at Morningstar wrote about Pfizer. However, "potential upside exists if larger demand for boosters emerges."

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In first interview, Bezos says space flight reinforced commitment to fighting climate change

Jeff Bezos said in an interview hours after flying to suborbital space on Tuesday that there are "no words" to adequately describe the experience, but that it reinforced his commitment to combatting climate change and keeping Earth "as this beautiful gem of a planet that it is."

Why it matters: Bezos, the world's richest man, said he plans to make Blue Origin and the Bezos Earth Fund — a $10 billion effort to fight climate change — his life focus moving forward.

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Senate Democrats announce $3.5 trillion budget reconciliation package

Senate Democrats on the Budget committee announced late Tuesday that they have reached a deal on a $3.5 trillion package to address "human" infrastructure, which they plan to pass via reconciliation.

Why it matters: The price tag comes in far below the $6 trillion figure Sen. Bernie Sanders, chairman of the committee, and other progressive Democrats have pushed for.

Editor's note: This a breaking news story. Please check back for updates.

Podcast: The art and business of political polling

The election is just eight days away, and it’s not just the candidates whose futures are on the line. Political pollsters, four years after wrongly predicting a Hillary Clinton presidency, are viewing it as their own judgment day.

Axios Re:Cap digs into the polls, and what pollsters have changed since 2016, with former FiveThirtyEight writer and current CNN politics analyst Harry Enten.

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