Sen. Joe Manchin (D-W.Va.) issued a statement on Wednesday saying he has "serious concerns" about the size of Democrats' $3.5 trillion budget reconciliation package, calling it "simply irresponsible" to continue spending at such high levels.

Why it matters: Senate Democrats cannot lose a single vote in order to pass President Biden's sweeping economic plan via reconciliation, a process that only requires 50 votes rather than the usual 60 to overcome a filibuster.

• Manchin and Sen. Kyrsten Sinema (D-Ariz.), another Democratic moderate, both voted to open debate on the budget resolution early Wednesday morning. But both have signaled doubts about the size of the package.
• Moderates in the House, where Democrats have a majority of just three votes, have also expressed serious concerns — setting up a high-stakes clash with progressives who have no interest in paring down the size of the bill.

What he's saying: "Over the past year, Congress has injected more than $5 trillion of stimulus into the American economy – more than any time since World War II – to respond to the pandemic," Manchin said.

• "Adding trillions of dollars more to nearly $29 trillion of national debt, without any consideration of the negative effects on our children and grandchildren, is one of those decisions that has become far too easy in Washington," he continued.
• "Given the current state of the economic recovery, it is simply irresponsible to continue spending at levels more suited to respond to a Great Depression or Great Recession – not an economy that is on the verge of overheating."
• "I firmly believe that continuing to spend at irresponsible levels puts at risk our nation’s ability to respond to the unforeseen crises our country could face. I urge my colleagues to seriously consider this reality as this budget process unfolds in the coming weeks and months."