Large shares of women, seniors and independents now say they're less likely to trust President Trump for accurate information about COVID-19 since he caught it himself, according to the latest installment of the Axios/Ipsos Coronavirus Index.

The big picture: Week 28 of our national survey has most Americans rejecting ideas that Trump has floated around hydroxychloriquine as a virus treatment, how herd immunity works or any imminent availability of a vaccine.

• Eight in 10 fear local cases will rise and force new lockdowns and business closures.
• Three-fourths of respondents say attending campaign rallies is risky.
• That's true for majorities of Republicans (54%) as well as independents (79%) and especially Democrats (93%) — and it suggests that Joe Biden's decision to scrap large events to protect the public and himself doesn't carry much political risk.

Why it matters: Trump can ill afford to lose more women, seniors or independents with two weeks until the end of the election, according to national and battleground state polls.

• The new findings reflect how the science around coronavirus is unifying Democrats but a wedge for Republicans — and how Trump's own messaging has painted him into a corner where he must rely more and more on his base to pick up the slack for others he's alienated.

What they're saying: “It makes it very hard for Donald Trump to steer public opinion about the pandemic," said pollster Chris Jackson, senior vice president for Ipsos Public Affairs.

• "It’s very hard for him to control the debate about COVID in any way because people have such little trust in what he says.”

By the numbers: Over the past two weeks, public opinion has turned more sharply against Trump's trustworthiness on information about the virus, from a 6 percentage point gap to 21.

• 37% of overall respondents in the most recent survey say his diagnosis makes them less likely to trust him, while 16% say they're more likely to trust him and the rest are unchanged.
• In the Oct. 1-5 survey, only 23% said they trusted him less and 17% said they were more likely to trust him.
• 62% of Democrats, 44% of seniors 65 and over, 41% of women and 40% of independents — but only 11% of Republicans — said they're less likely to trust Trump's guidance now when it comes to the virus.

Between the lines: Republicans are far more likely than Democrats or independents to incorrectly believe that hydroxychloroquine was proven an effective treatment; that a vaccine would be available by election day; or that the U.S. could reach herd immunity with only a few additional deaths.

• Republicans also are less likely to say it is true there was a pause in some trials due to safety concerns; that the virus can be spread without symptoms; or that wearing a mask limits person-to-person spread.
• 71% of Democrats, 58% of independents and 27% of Republicans answered all six questions correctly.
• More than one in five Republicans got half or more of the questions wrong, compared with around 7% of Democrats.
• People with no major source of news or who primarily watch Fox News had the highest correlations to incorrect answers.

Methodology: This Axios/Ipsos Poll was conducted Oct.16–19 by Ipsos’ KnowledgePanel®. This poll is based on a nationally representative probability sample of 1,001 general population adults age 18 or older.

• The margin of sampling error for the full sample is +/- 3.3 percentage points.